When I read newspaper comics as a kid, Nancy seemed like the laziest of all the comics. The art was extremely simple, the characters were stuck in 1930's, and it was never funny. Later versions played up the cheesecake appeal of Aunt Fritzi, but did not add any humor. I was surprised to learn that in 2018 a new creator took over Nancy and made it a cult favorite.
The humor of the new Nancy strip is very meta. The characters directly reference the fact that they are in a comic strip and are being written and drawn. The characters now live in a world with smart phones and the internet, but still dress like extras from an Our Gang short. The biggest change is that the creator is clearly trying to be funny, and succeeds quite frequently. This is not Calvin & Hobbes, but it hits at least 1 in 6, which is way higher than the average for contemporary comic strips.