I have followed the Fables series from the start back in 2002 and it has never been less than entertaining. While ostensibly a fantasy soap opera, Willingham has used Fables to explore themes of family, duty and individual freedom. The series was always surprising and often I picked up new issues without the slightest idea what was going to happen next, and that is very rare in comics.
It is not the easiest series to recommend because with 22 volumes it requires a hefty commitment of time and money just to read it, but I do recommend it. I suggest you borrow the first volume from your local library or from a friend and once you start it you will want to see it through to the end.
No spoilers about the ending, but the creators do tie up most of the plot lines while scattering dozens of seeds for future stories in case they ever decide to return to the world of Fables.